- Louise Brown, 33, was the world's first child conceived with IVFÂ
- She says weeks without mother Lesley has been the worst of her life
By Polly Dunbar
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Special Bond: Lesley and John Brown with baby Louise shortly after her birth in 1978
To anybody who spots her on the street, juggling her shopping and her boisterous five-year-old son, Louise Brown looks like any other young, slightly harassed mother.
Everything about her â" from her defiantly unpolished appearance and no-nonsense demeanour to her job as an administrator for a shipping firm â" is resolutely ordinary, with no hint she has spent her entire life in the spotlight.
Yet Louise was the first baby to be born as the result of in vitro fertilisation, and as a result of this unique aspect of her existence she has shared every milestone with the world, from her first birthday to the birth of her son, Cameron.
That she has managed to emerge from it all so utterly down-to-earth is testimony, she knows now better than ever, to the happiness and stability of her upbringing.
For the 33-year-old is going through perhaps the most difficult rite of passage of all. Earlier this month, her mother Lesley died suddenly, a fter developing septicaemia while being treated in hospital for gallstones.
The pair were exceptionally close, especially so since the death five years ago of her father, John, from lung cancer.
Everybody who has lost a loved one can identify with Louiseâs grief. Yet the circumstances of her birth gave the bond with her mother a special intensity, and make Lesleyâs death at 64 particularly poignant.
It was Lesleyâs desperation to become a mother that led her to take a chance with an experimental procedure that had never previously worked for other couples.
She was a shy, self-effacing woman, but with a bravery and determination that changed history.

Louise, right, with Lesley in the background, pictured in 2010
âI donât think Mumâs death has really hit me yet,â Louise says. âThe past few weeks have been the worst of my life.
'Iâve cried so much that I feel like Iâm all cried out and then something silly, like a piece of music or something on the TV or a comment from Cameron, will set me off again.
The tributes to Mum have been lovely. People from all over the world have written messages to say what a fantastic pioneer she was.
She would have laughed at the word âpioneerâ, though.
Sheâd say she wasnât brave; she just wanted a family so badly she was prepared to do anything. But she was quietly determined.
âI donât think I could have tried for a baby for as long as she did. Iâd have given up, but she never did.
Lesley pictured holding flowers, left and with husband John Brown at Oldham General Hospital before giving birth to Louise in July 1978
She gave me life â" and every woman the chance to be a mother.â
She adds: âTo me, she was just a normal mum. She was so kind and giving and I canât think of anything important which has happened to me without her being there.
She helped me organise my wedding; she was there when I gave birth to Cameron.
âI canât imagine what lifeâs going to be like without her, but I was brought up to get on with things, so thatâs what Iâm doing.â
Lesleyâs funeral was last week, and making the arrangements has kept Louise, her elder half-sister Sharon â" her fatherâs child by an earlier partner â" and her younger sister Natalie busy.

Louise pictured on the Daily Mail's front page 18 hours old in 1978
But she is clearly still in a state of shock over the loss of her mother, who lived just ten minutes away from the home in Bristol she shares with her husband, Wesley Mullinder.
Lesley was being treated in Bristol Royal Infirmary when it became clear she would not survive the blood infection she had contracted.
âIt was such a shock,â Louise says. âWhen we were told there was nothing they could do, my sisters and I made the decision to switch off her life- support, and we were all with her to say goodbye and hold her hand at the end, which made it easier.
âAfterwards, I went straight home to tell Cameron, which I found very difficult. Mum picked him up from school most days and cared for him until I got back from work and he loved her very much.â
In many ways, Louiseâs ordinariness has always been part of what has made her story so charming. To those who feared her birth heralded a new era of scientists âplaying Godâ with impunity, she is a living contradiction.
When she was born on July 25, 1978, the first success from pioneers Patrick Steptoe, a gynaecologist, and Dr Robert Edwards, a biologist, in Oldham, the Vatican said it could have âgrave consequences for humanityâ.
Even James Watson, the DNA pioneer, warned that the scientists were dabbling in infanticide.
But to her working-class parents she was simply the perfect baby they had spent nine years trying for.
Of course, when Lesley and John first agreed to the treatment, which involved an egg being removed from one of Lesleyâs ovaries with a probe and mixed in a petri dish â" not a test tube â" with Johnâs sperm and the resulting embryo being implanted in Lesleyâs womb two days later, they had little idea of its significance.
âMum knew it had been tried before but she didnât realise that it had never resulted in a baby,â says Louise.
âIt wasnât until near the end of her pregnancy that she understood it would be a world first, which I think is good.

IVF pioneer Professor Robert Edwards who made the in vitro fertilisation possible, Lesley Brown, and Louise Brown, 30 with her son Cameron at the 30th anniversary of Louise's birth in Cambridgeshire in 2008
'She was a worrier and if sheâd known, it might not have worked.â
From the moment of Louiseâs birth, for which reporters and television crews from six continents set up camp outside the hospital, every aspect of her formative years was subject to international attention.
At first John and Lesley were happy to give interviews and travel the world showing off their miracle baby, but they soon began to find the fame oppressive.

Lesley Brown, the first woman in the world to successfully give birth following IVF treatment, has died at the age of 64
âMum always hated the attention,â says Louise. âRecently, I was transferring some of our old videos on to DVD and I saw a programme which was made when I was about six months old.
I noticed that all the questions were directed to my dad because my mum was just sitting there.
If she was asked something directly, she would answer, but she was obviously uncomfortable. She was shy and quiet.
âSheâd sometimes say she felt like I wasnât her baby; that she was sharing me with the world.
'S he didnât like it. She wanted me to grow up in a normal way. After a while she and my dad decided they wanted to limit the publicity. They both tried hard to protect me.â
All the attention from strangers might have made Louise feel special, but she insists she didnât.
However, she admits: âOf course I knew people were interested in me â" wherever I went as a child people wanted to ask me questions. I liked talking to them.
âMy parents got media requests from all over the world every week, but they limited the press I did to certain milestones, when they knew we wouldnât be able to avoid the attention. They were very practical about it.
âI remember a TV company calling them once to ask if we could fly to America the next day.
I got excited about it, but they explained they had jobs and we couldnât just drop everything and go.â
She was four â" around the time her younger sister Natalie, also conceived via IVF, was born â" when her parents tried to explain her conception.

Louise Brown, centre, and her parents, Lesley and John, who passed away five years ago. Louise has paid tribute to her mother saying she can't imagine what life will be like without her
Concerned that the older children at school might tease her, they told her about her âunclesâ who pioneered the IVF process.
âMum and Dad showed me the video of my birth and told me that although I was the same as everyone else, the way I was made was slightly different.
Over the years, Iâd hear people talking about it, and as I got older I started to understand what it meant.
âKids at school would mention it and sometimes theyâd shout âtest-tube babyâ at me, but they werenât nasty, just interested because it was something different.
'Mum didnât like that term at the start because she thought it made me sound like an experiment, but Iâve never minded; itâs just a short-hand for IVF and everyone uses it.
âI never felt isolated from other kids. Iâm outgoing and I love chatting â" the opposite of Mum, really.â
Despite Lesleyâs best efforts to shield her daughter, photographers lurking outside the family home were a constant throughout Louiseâs childhood.

A mother's love: Lesley and Louise Brown pictured shortly after coming home from the hospital in 1978
She was determined that it would not alter the upbringing she wanted for her daughter, and she managed to make it as unremarkable as possible, with family horse-riding and swimming excursions.
Spotting reporters became a family joke, one which brought them closer together.
âWhen I think about Mum during my childhood, I just think about the fact that she was always there,â says Louise.
âWhatever my sister and I needed, she gave us.
She was a very gentle person and very stable. She worried for me, but because she was always there, I was never worried about anything.â
For all Louiseâs determinedly positive outlook, there were undoubtedly aspects of their fame which were painful for the family.
âOver the years there have been some cruel and hurtful things written about me, which Mum found difficult,â she admits.
âIâve always been big and I donât mind, but it wasnât nice for Mum to have to see comments about the âthingâ she created.
âOn a website this week, I saw someone had written: âI hope Lesleyâs death wasnât a result of her IVFâ. People can be very ignorant. I felt like replying to say, âOf course notâ, but I know I canât.â
As she grew older, Louiseâs reliance on her mother continued.
When she first met Wesley, a nightclub doorman, in 2002, the couple moved into her parentsâ home until they could afford their own house.
It was Lesley she called first when she became engaged and Lesley who was by her si de when she gave birth to Cameron by caesarean in December 2006 â" the day after her fatherâs death.
âI donât know if the fact Mum tried so hard to have me had an effect on me, but I always wanted children, and I was lucky to conceive naturally after only six months of trying,â she says.
Lesley proved herself to be not only an extraordinary mother, but grandmother, too. âFrom the moment he was born, she helped me so much,â says Louise.

Lesley, John and Louise Brown return to Oldham General Hospital in 1979 to see the nurses that helped during her birth
âShe even showed me how to give him his first bath because I didnât know what I was doing. When I went back to work, she had him every day.âÂ
Although she believes wholeheartedly in IVF, like many others, Louise worries about the consequences of the advances which have followed since her conception.
âIVF has helped millions of couples have babies. Of course Iâd have had it myself if Iâd needed to,â she says.Â
âI donât have strong feelings about surrogacy â" if itâs used properly it can help women who canât carry a child.
'Iâm happy for same-sex couples to use IVF to have a baby, but I donât believe couples should be able to choose the sex or anything else of their child unless itâs for medical reasons.â
Her biggest concern is over the increasing numbers of women having treatment to conceive babies long past the age they would be able to naturally.
âChildren need their parents to be there, so I believe in having children young, to see as much of their lives as possible,â she says.
âI can understand why some older women might be desperate for a family if they havenât had one, but Iâd be worried about women in their fifties having a baby just because they can.â
At 33, she is young to have had her own parents taken from her, but it is the practical attitude her mother instilled in her which will ensure she is able to cope.
Her death has made Louise think more deeply about motherhood.
âI keep thinking what a brilliant mother she was, to make things so secure for us even though sheâd suddenly been plunged into a crazy situation,â she says. â
âShe wouldnât want me moping about,â she says.
âBesides, when youâre a mum, you have to carry on. If I can do as good a job as her, Iâll be happy.â
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I remember Louise being born, and have watched her over the years. Just like the Liverpool sextuplets and the TV series 7up 14 21 28 35 42 49 and the latest 56up. They are almost like my brothers and sisters. It seems daft, I know. But I love to hear about them. Condolences to Louise and her family.
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Wow, absolutely amazing seeing those pictures. First, I'm sadden by Lesley Brown's death ... 64 is too young to pass away and I'm sorry her grandson only got to know her for a few years. The news of the Louise Brown's birth was big news in the U.S.; I don't recall seeing any pictures of the parents during this time as the parents didn't seem to want to draw attention to themselves and they wanted to raise their daughter as any other parents. I seemed to remember one picture Louise at 2 and it was reported that she was happy normal. There was a lot of interest in the U.S. of this because the method was so unusual and no-one was quite sure it would work and also because the anti-abortion movement was starting to flex its muscle in America at this time and reproduction rights were in the news. I remember - as an 11 year old - that being the "test tube baby" that she was created by the scientists; boy, those were the days.
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Fiat Lux - why would you like a more precise diagnosis? What business is it of yours? Condolences to Louise and family.
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Although I personally do not agree with this procedure, that is my choice and I cannot deny it. My wife and I would have been utterly devastated if we could not have had opur only child......But...I must say that this young lady has turned out to be a well adjusted and apparently a very nice person....It is always sad when you lose a parent at such a young age. Thankfully she has a good husband and a young boy to share her life with....Best wishes to you all.
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I remember when Louise Brown was born, she was a miracle at that time, her mother was truly blessed to have such a lovely daughter, so sad to hear of her passing. She had 34 years of a wonderful life as a mother and I am sure she thanked god every one of those days.
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god rest her soul, she was a lovely women just like her daughter is .
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they seem a lovely family... condolences
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Fiat Lux, Unfortunately, Septicaemia is more than just a blood infection, if you did a bit of research you would know this, and its not caused by any failure of hospital staff. People may survive simple or complex surgery but if this infection takes hold the outlook is very bleak, I've had two family members die from this very infection. Thoughts are with Louise and her family, I remember all the interest in her birth
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A ''Blood infection '' is usually eminently treatable . I would like a more precise diagnosis . There is no enough detail here .
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Lovely to read the following bit, sounds like the perfect mum, my condolences: âWhen I think about Mum during my childhood, I just think about the fact that she was always there,â says Louise. âWhatever my sister and I needed, she gave us. She was a very gentle person and very stable. She worried for me, but because she was always there, I was never worried about anything.â
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